{"id":379,"date":"2026-06-16T22:18:40","date_gmt":"2026-06-16T15:18:40","guid":{"rendered":"https:\/\/dnacenter.thaizone.net\/researchers-discover-a-potential-way-to-hit-an-elusive-target-in-pancreatic-cancer\/"},"modified":"2026-06-16T22:18:40","modified_gmt":"2026-06-16T15:18:40","slug":"researchers-discover-a-potential-way-to-hit-an-elusive-target-in-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/dnacenter.thaizone.net\/en\/researchers-discover-a-potential-way-to-hit-an-elusive-target-in-pancreatic-cancer\/","title":{"rendered":"Researchers discover a potential way to hit an elusive target in pancreatic cancer"},"content":{"rendered":"<p>&nbsp;<span style=\"background-color: rgb(255, 255, 251); color: rgb(46, 46, 46); font-family: &quot;Noto Sans&quot;, &quot;Century Gothic&quot;, Arial, sans-serif;\">Three independent studies suggest a way to indirectly thwart a mutated gene that drives tumor growth in 95% of people with pancreatic cancer.<\/span><\/p>\n<p style=\"box-sizing: border-box; margin-top: 1.25em; margin-bottom: 1.25em; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-stretch: inherit; line-height: 1.5em; font-family: &quot;Noto Sans&quot;, &quot;Century Gothic&quot;, Arial, sans-serif; vertical-align: baseline; direction: ltr; text-rendering: optimizelegibility; color: rgb(46, 46, 46); background-color: rgb(255, 255, 251);\">The changed gene,&nbsp;<em style=\"box-sizing: border-box; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline;\">KRAS<\/em>, has proven to be one of the most elusive targets in cancer research.<\/p>\n<p style=\"box-sizing: border-box; margin-top: 1.25em; margin-bottom: 1.25em; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-stretch: inherit; line-height: 1.5em; font-family: &quot;Noto Sans&quot;, &quot;Century Gothic&quot;, Arial, sans-serif; vertical-align: baseline; direction: ltr; text-rendering: optimizelegibility; color: rgb(46, 46, 46); background-color: rgb(255, 255, 251);\">Currently there are no approved drugs that target mutated KRAS proteins (made from the altered&nbsp;<em style=\"box-sizing: border-box; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline;\">KRAS<\/em>&nbsp;gene) directly. There are drugs that target KRAS indirectly by blocking proteins that interact with it, but they have been ineffective against&nbsp;<a data-entity-substitution=\"canonical\" data-entity-type=\"node\" href=\"https:\/\/www.cancer.gov\/types\/pancreatic\/patient\/pancreatic-treatment-pdq\" data-entity-uuid=\"4ab7609b-e052-4749-8abc-dc3b0ff4a10c\" style=\"box-sizing: border-box; border-width: 0px; border-style: initial; font: inherit; vertical-align: baseline; color: rgb(43, 123, 186);\">pancreatic cancer<\/a>&nbsp;in clinical studies.<\/p>\n<p style=\"box-sizing: border-box; margin-top: 1.25em; margin-bottom: 1.25em; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-stretch: inherit; line-height: 1.5em; font-family: &quot;Noto Sans&quot;, &quot;Century Gothic&quot;, Arial, sans-serif; vertical-align: baseline; direction: ltr; text-rendering: optimizelegibility; color: rgb(46, 46, 46); background-color: rgb(255, 255, 251);\">In these new studies, however, the researchers found that drugs that block the activity of KRAS-interacting proteins force cancer cells to rely on a way of creating energy called&nbsp;<a class=\"definition\" href=\"https:\/\/www.cancer.gov\/Common\/PopUps\/popDefinition.aspx?id=CDR0000561319&amp;version=Patient&amp;language=English\" style=\"box-sizing: border-box; border-width: 0px 0px thin; border-top-style: initial; border-right-style: initial; border-bottom-style: dotted; border-left-style: initial; font: inherit; vertical-align: baseline; color: rgb(46, 46, 46);\">autophagy<\/a>. They<\/p>\n<p style=\"box-sizing: border-box; margin-top: 1.25em; margin-bottom: 1.25em; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-stretch: inherit; line-height: 1.5em; font-family: &quot;Noto Sans&quot;, &quot;Century Gothic&quot;, Arial, sans-serif; vertical-align: baseline; direction: ltr; text-rendering: optimizelegibility; color: rgb(46, 46, 46); background-color: rgb(255, 255, 251);\">Read more<\/p>","protected":false},"excerpt":{"rendered":"<p>&nbsp;Three independent studies suggest a way to indirectly thwart a mutated gene that drives tumor growth in 95% of people with pancreatic cancer. The changed gene,&nbsp;KRAS,<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-379","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/posts\/379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/comments?post=379"}],"version-history":[{"count":0,"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/posts\/379\/revisions"}],"wp:attachment":[{"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/media?parent=379"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/categories?post=379"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnacenter.thaizone.net\/en\/wp-json\/wp\/v2\/tags?post=379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}